How Trulance works
Trulance replicates what bodies may do naturally*
Trulance is the only medication for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) that is nearly identical to uroguanylin,† a peptide (building block of protein) that occurs naturally in your body. To best understand how uroguanylin works, let’s take a closer look at what happens in your body during the process of digestion.
- After you eat, food is broken down in the stomach and the intestines
- In the digestion process, fluid helps to form the consistency of the stool created from the waste that's left behind
- When there is too little fluid, it may result in constipation, while too much may result in diarrhea
- Uroguanylin works best in the small intestine, where—based on the changing pH levels—it provides the right amount of fluid to create well-formed stool*
- Uroguanylin has also been shown to reduce stomach pain*
*This activity was seen in animal studies. The relevance to humans is not yet known.
†Pronounced “yur-oh-gwah-nih-lin.”
How do Trulance and uroguanylin differ?
Trulance is very similar to naturally occurring uroguanylin, with exception of a single small molecular difference that improves how Trulance attaches in the small intestine.
Where in the body does Trulance work?
Trulance is thought to work primarily in the small intestine.*
*This activity was seen in animal studies. The relevance to humans is not yet known.
