How Trulance works

Trulance replicates what your body does naturally*

Trulance is the first medication for Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome with Constipation (IBS-C) that's designed to work like a natural peptide in your body called uroguanylin (pronounced “yur-oh-gwah-nih-lin”). To best understand how uroguanylin works, let’s take a closer look at what happens in your body during the process of digestion.

  1. After you eat, food is broken down in the stomach and the intestines
  2. In the digestion process, fluid helps to form the consistency of the stool created from the waste that's left behind
  3. When there is too little fluid, it may result in constipation, while too much may result in diarrhea
  4. Uroguanylin is found in the GI tract and works best in the small intestine where—based on the changing pH levels of this area—it provides the appropriate amount of fluid to create well-formed stool*
  5. Uroguanylin has also been shown to reduce abdominal pain*

    *This activity was seen in animal studies. The relevance to humans is not yet known.

What’s the difference between Trulance and uroguanylin?

Trulance is very similar to the uroguanylin that your body naturally makes, with the exception of a single small change in the Trulance molecule that improves how it attaches in the small intestine.

Where in the body does Trulance work?

Trulance is thought to work primarily in the small intestine.


This activity was seen in animal studies. The relevance to humans is not yet known.